Phosphorus oxychloride → 4-Chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

反応式

[C:1]([C:3]1[O:7][N:6]=[CH:5][CH:4]=1)#[N:2].[NH2:8][C:9]1[S:10][C:11]([CH2:19][CH3:20])=[CH:12][C:13]=1[C:14](OCC)=O.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:14]1[C:13]2[CH:12]=[C:11]([CH2:19][CH3:20])[S:10][C:9]=2[N:8]=[C:1]([C:3]2[O:7][N:6]=[CH:5][CH:4]=2)[N:2]=1

参加物

反応物 3

HCID 24813Phosphorus oxychloride

HCID 78263Ethyl 2-amino-5-ethyl-3-thenoate

HCID 112287641,2-Oxazole-5-carbonitrile

生成物 1

HCID 184600984-Chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

実験手順

With the procedure of Example 477, the reaction of 5-cyanoisoxazole and 2-amino-5-ethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(isoxazol-5-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine

出典と根拠

ORDレコード: ord-9738ace19e054fac9d37052414aa8e5a
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133271

反応ノート

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