Phosphorus oxychloride → 4-Chloro-2-(pyrazin-2-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine
反応式
[C:1]([C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([C:20]([F:23])([F:22])[F:21])=[CH:13][C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:26]>>[Cl:26][C:15]1[C:14]2[CH:13]=[C:12]([C:20]([F:21])([F:22])[F:23])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:8]=[N:7][CH:6]=[CH:5][N:4]=2)[N:2]=1参加物
4
実験手順
With the procedure of Example 477, the reaction of 2-cyanopyrazine and 2-amino-5-trifluoromethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyrazin-2-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine
出典と根拠
- ORDレコード
- ord-85a979fab9fa4efabf64abe2dd036d82
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133271
反応ノート
読み込み中…