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4-Cyanopyridine → 4-Chloro-2-(pyridin-4-yl)-6-methyl-thieno-[2,3-d]-pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Cyanopyridine | HCID 7506 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| 生成物 | 4-Chloro-2-(pyridin-4-yl)-6-methyl-thieno-[2,3-d]-pyrimidine | HCID 18460524 | — |
反応手順
With the procedure of Example 477, the reaction of 4-cyanopyridine and 2-amino-5-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-4-yl)-6-methyl-thieno-[2,3-d]-pyrimidine
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133271 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-773031dadf164ec1aa04ff65cd1eb869 |
| 出典メモ | uspto-grants-2000_10 |