4-Cyanopyridine → 4-Chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine

反応式

[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([CH3:21])=[C:13]([CH3:20])[C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:24]>>[Cl:24][C:15]1[C:14]2[C:13]([CH3:20])=[C:12]([CH3:21])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)[N:2]=1

参加物

反応物 3

HCID 75064-Cyanopyridine

HCID 24813Phosphorus oxychloride

HCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoate

生成物 1

HCID 184604944-Chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine

実験手順

With the procedure of Example 477, the reaction of 4-cyanopyridine and 2-amino-4,5-dimethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-4-yl)-5,6-dimethyl-thieno-[2,3-d]-pyrimidine

出典と根拠

ORDレコード: ord-ea58be6a11cd4f56999cfeeb4e5b8ec7
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133271

反応ノート

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