Benzylamine → 2-(Isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

反応式

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[C:11]2[C:23]([CH3:24])=[CH:22][S:21][C:12]=2[N:13]=[C:14]([C:16]2[O:20][N:19]=[CH:18][CH:17]=2)[N:15]=1>>[O:20]1[C:16]([C:14]2[N:15]=[C:10]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:11]3[C:23]([CH3:24])=[CH:22][S:21][C:12]=3[N:13]=2)=[CH:17][CH:18]=[N:19]1

参加物

反応物 2

HCID 7504Benzylamine

HCID 184601204-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

生成物 1

HCID 184601632-(Isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

実験手順

With the procedure of Example 1, the reaction of benzylamine with 4-chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine.

出典と根拠

ORDレコード: ord-dd646350b90f4dc0b0cbe8c3879a4326
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133271

反応ノート

読み込み中…