4-Fluorobenzylamine → 2-(Pyrazin-2-yl)-4-(4-fluorobenzylamino)-6-chloro-thieno-[2,3-d]-pyrimidine

反応式

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.Cl[C:11]1[C:12]2[CH:25]=[C:24]([Cl:26])[S:23][C:13]=2[N:14]=[C:15]([C:17]2[CH:22]=[N:21][CH:20]=[CH:19][N:18]=2)[N:16]=1>>[N:18]1[CH:19]=[CH:20][N:21]=[CH:22][C:17]=1[C:15]1[N:16]=[C:11]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[C:12]2[CH:25]=[C:24]([Cl:26])[S:23][C:13]=2[N:14]=1

参加物

反応物 2

HCID 673264-Fluorobenzylamine

HCID 184601094-Chloro-2-(pyrazin-2-yl)-6-chloro-thieno-[2,3-d]-pyrimidine

生成物 1

HCID 184599472-(Pyrazin-2-yl)-4-(4-fluorobenzylamino)-6-chloro-thieno-[2,3-d]-pyrimidine

実験手順

With the procedure of Example 1, the reaction of 4-fluorobenzylamine with 4-chloro-2-(pyrazin-2-yl)-6-chloro-thieno-[2,3-d]-pyrimidine yields 2-(pyrazin-2-yl)-4-(4-fluorobenzylamino)-6-chloro-thieno-[2,3-d]-pyrimidine.

出典と根拠

ORDレコード: ord-a79f573a70b04ae5ac5cbd1d5ce0a864
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133271

反応ノート

読み込み中…