Ethyl 2-fluoro-5-nitrocarbanilate → Ethyl 5-amino-2-fluorocarbanilate

HRID 36798ノート

反応式

HRID 36798 の反応式
[F:1][C:2]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:3]=1[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8].[H][H]>[C].[Pd].C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:2]([F:1])=[C:3]([CH:10]=1)[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8]

参加物

5

反応物 2

HCID 2754990Ethyl 2-fluoro-5-nitrocarbanilateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 19937926Ethyl 5-amino-2-fluorocarbanilate収率 81%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

100.3 mg (10 wt %) of 5% palladium carbon (containing water) was added to a mixture of 1.00 g (4.39 mmol) of ethyl 2-fluoro-5-nitrocarbanilate and 20 ml of ethanol, and the resultant mixture was stirred until 309 ml of hydrogen was absorbed. The reaction mixture was filtered to remove the catalyst, and the solvent was then distilled off under a reduced pressure. Thus, 700 mg of the objective product (yield: 81%) was obtained in the form of light brown crystals.

後処理

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. customto remove the catalyst
  4. distillationthe solvent was then distilled off under a reduced pressure

出典と根拠

ORDレコード
ord-b0f5a2a0fb2a496cacb3d62cd4530814
出典データセット
uspto-grants-1995_05
特許番号
US05416236

反応ノート

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