Chlorine → Ethyl 4-chloro-5-ethylsulfonylamino-2-fluorocarbanilate

HRID 36800ノート

反応式

HRID 36800 の反応式
[CH2:1]([S:3]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([F:19])=[C:11]([CH:18]=1)[NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])(=[O:5])=[O:4])[CH3:2].[Cl:20]Cl>O1CCOCC1.O>[Cl:20][C:8]1[C:7]([NH:6][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:18][C:11]([NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])=[C:10]([F:19])[CH:9]=1

参加物

5

反応物 2

HCID 24526ChlorineHCID 10891582Carbamic acid, [5-[(ethylsulfonyl)amino]-2-fluorophenyl]-, ethyl ester

生成物 1

HCID 10903456Ethyl 4-chloro-5-ethylsulfonylamino-2-fluorocarbanilate収率 86%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

0.50 g (1.72 mmol) of ethyl 5-ethylsulfonylamino-2-fluorocarbanilate was dissolved in a mixture of 5 ml of dioxane and 1 ml of water, and chlorine gas was added to the resultant solution at a temperature of not higher than 25° C. until the starting material disappeared. After the reaction was completed, the surplus chlorine gas was removed by blowing nitrogen gas thereinto, and water was added. The precipitates crystals were filtered out and dried to obtain 0.48 g of the objective product (yield: 86%) in the form of light brown crystals.

後処理

  1. customthe surplus chlorine gas was removed
  2. additionwater was added
  3. filtrationThe precipitates crystals were filtered out
  4. customdried

出典と根拠

ORDレコード
ord-37eb7b14a6974094b8b91fc26352c817
出典データセット
uspto-grants-1995_05
特許番号
US05416236

反応ノート

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