Chlorine → HCID 19937923、化合物

HRID 36801ノート

反応式

HRID 36801 の反応式
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([F:18])=[C:10]([CH:17]=1)[NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])(=[O:4])=[O:3].[Cl:19]Cl>C(O)(=O)C.O>[Cl:19][C:7]1[C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:17][C:10]([NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])=[C:9]([F:18])[CH:8]=1

参加物

5

反応物 2

HCID 24526ChlorineHCID 19937925Ethyl 5-methylsulfonylamino-2-fluorocarbanilate

生成物 1

HCID 19937923HCID 19937923、化合物収率 90%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

80.6 g (292 mmol) of ethyl 5-methylsulfonylamino-2-fluorocarbanilate was dissolved in a mixture of 1075 ml of acetic acid and 100 ml of water, and chlorine gas was added to the resultant solution at a temperature of not higher than 25° C. until the starting material disappeared. After the reaction was completed, the surplus chlorine gas was removed by blowing nitrogen gas thereinto, and hexane was added. The precipitates crystals were filtered out to obtain 81.4 g of the objective product (yield: 90%) in the form of yellow crystals.

後処理

  1. customthe surplus chlorine gas was removed
  2. additionhexane was added
  3. filtrationThe precipitates crystals were filtered out

出典と根拠

ORDレコード
ord-37edf1745ff24e0d9bc9313ecf7b3020
出典データセット
uspto-grants-1995_05
特許番号
US05416236

反応ノート

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