Hydrogen Peroxide → 2,3-Difluorophenol
反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.[OH:12]O>CCOCC>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:12]参加物
4
実験手順
The boronic acid in an amount of 9.0 g was dissolved in 60 ml of an ether, and the solution thus formed was added dropwise with 60 ml of a 10% aqueous hydrogen peroxide while being refluxed under a heated condition. After the dropping of the aqueous hydrogen peroxide was finished, the reflux under a heated condition was further continued for 2 hours. Then, the ether layer was separated with a separating funnel, washed with water, dried, and then subjected to distillation under a reduced pressure to separate the solvent to obtain 7.1 g of 2,3-difluorophenol.
後処理
- customthe solution thus formed
- temperaturewhile being refluxed under a heated condition
- temperaturethe reflux under a heated condition
- customThen, the ether layer was separated with a separating funnel
- washwashed with water
- customdried
- distillationsubjected to distillation under a reduced pressure
- customto separate the solvent
出典と根拠
- ORDレコード
- ord-5126645cd7c5425d9a55f5c7ca5fdb54
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05417885
反応ノート
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