Hydrogen Peroxide → 2,3-Difluorophenol

The boronic acid in an amount of 9.0 g was dissolved in 60 ml of an ether, and the solution thus formed was added dropwise with 60 ml of a 10% aqueous hydrogen peroxide while being refluxed under a heated condition. After the dropping of the aqueous hydrogen peroxide was finished, the reflux under a heated condition was further continued for 2 hours. Then, the ether layer was separated with a separating funnel, washed with water, dried, and then subjected to distillation under a reduced pressure to separate the solvent to obtain 7.1 g of 2,3-difluorophenol.

1. customthe solution thus formed
2. temperaturewhile being refluxed under a heated condition
3. temperaturethe reflux under a heated condition
4. customThen, the ether layer was separated with a separating funnel
5. washwashed with water
6. customdried
7. distillationsubjected to distillation under a reduced pressure
8. customto separate the solvent

ORDレコード

ord-5126645cd7c5425d9a55f5c7ca5fdb54

出典データセット

uspto-grants-1995_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05417885