Water → 4-Bromo-2-fluoroanisole

HRID 36820

反応式

HRID 36820 の反応式
C(=S)=S.[Br:4]Br.O.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH3:15]>>[Br:4][C:12]1[CH:11]=[CH:10][C:9]([O:14][CH3:15])=[C:8]([F:7])[CH:13]=1

参加物

5

反応物 4

HCID 962WaterHCID 6348Carbon DisulfideHCID 24408BromineHCID 675762-Fluoroanisole

生成物 1

HCID 753784-Bromo-2-fluoroanisole

実験手順

To 50 ml of carbon disulfide in which 50 g of o-fluoroanisole was dissolved, a solution prepared by mixing 27 g of carbon dislufide with 63.8 g of bromine was slowly added dropwise at a temperature of -5° C. to 5° C. in 1 hour with stirring. After the dropping of the solution was finished, it was further stirred at 5° C. for 30 min, added with 125 ml of water, and subjected to extraction with chloroform. The chloroform layer was washed with an aqueous sodium thiosulfate (Na2S2O3) solution and an aqueous sodium hydrogencarbonate (NaHCO3) solution in turn. Then, the solvent was distilled off with an evaporator under a reduced pressure to obtain 70.9 of 4-bromo-2-fluoroanisole.

後処理

  1. customa solution prepared
  2. additionwas slowly added dropwise at a temperature of -5° C. to 5° C. in 1 hour
  3. stirringit was further stirred at 5° C. for 30 min
  4. extractionsubjected to extraction with chloroform
  5. washThe chloroform layer was washed with an aqueous sodium thiosulfate (Na2S2O3) solution
  6. distillationThen, the solvent was distilled off with an evaporator under a reduced pressure

出典と根拠

ORDレコード
ord-c715292aa3f54317b7717fceb9860af9
出典データセット
uspto-grants-1995_05
特許番号
US05417885

関連ノート

読み込み中…