Water → 4-Bromo-2-fluoroanisole
反応式
C(=S)=S.[Br:4]Br.O.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH3:15]>>[Br:4][C:12]1[CH:11]=[CH:10][C:9]([O:14][CH3:15])=[C:8]([F:7])[CH:13]=1参加物
5
実験手順
To 50 ml of carbon disulfide in which 50 g of o-fluoroanisole was dissolved, a solution prepared by mixing 27 g of carbon dislufide with 63.8 g of bromine was slowly added dropwise at a temperature of -5° C. to 5° C. in 1 hour with stirring. After the dropping of the solution was finished, it was further stirred at 5° C. for 30 min, added with 125 ml of water, and subjected to extraction with chloroform. The chloroform layer was washed with an aqueous sodium thiosulfate (Na2S2O3) solution and an aqueous sodium hydrogencarbonate (NaHCO3) solution in turn. Then, the solvent was distilled off with an evaporator under a reduced pressure to obtain 70.9 of 4-bromo-2-fluoroanisole.
後処理
- customa solution prepared
- additionwas slowly added dropwise at a temperature of -5° C. to 5° C. in 1 hour
- stirringit was further stirred at 5° C. for 30 min
- extractionsubjected to extraction with chloroform
- washThe chloroform layer was washed with an aqueous sodium thiosulfate (Na2S2O3) solution
- distillationThen, the solvent was distilled off with an evaporator under a reduced pressure
出典と根拠
- ORDレコード
- ord-c715292aa3f54317b7717fceb9860af9
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05417885
反応ノート
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