Acetyl chloride → 1-Acetyl-4-(4-phenylphenyl)benzene

HRID 36824

反応式

HRID 36824 の反応式
C1([C:7]2[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:9][CH:10]=[CH:11][CH:12]=2)C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20].[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[C:19]([C:16]1[CH:17]=[CH:18][C:13]([C:8]2[CH:9]=[CH:10][C:11]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:12][CH:7]=2)=[CH:14][CH:15]=1)(=[O:21])[CH3:20]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 6766O-TerphenylHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 37444721-Acetyl-4-(4-phenylphenyl)benzene収率 119%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
-5 °C

実験手順

After a mixture of 172 g of terphenyl, 860 ml of benzene, and 353 g of acetyl chloride was cooled to -5° C., it was added with a total of 200 g of anhydrous aluminium chloride in few instalments, and subjected to reaction at -5° C. for 1 hour and further at 10° C. for 1 hour. The solid materials thus formed were separated by filtration, washed with a total of 4 liter of methanol in few instalments, and then recrystallized from chloroform to obtain 121 g of 4-acetyl-p-terphenyl, 2. The yield was 59%.

後処理

  1. customsubjected to reaction at -5° C. for 1 hour and further at 10° C. for 1 hour
  2. customThe solid materials thus formed
  3. customwere separated by filtration
  4. washwashed with a total of 4 liter of methanol in few instalments
  5. customrecrystallized from chloroform

出典と根拠

ORDレコード
ord-fcf69c324b7543df958050b25c92f785
出典データセット
uspto-grants-1995_05
特許番号
US05417885

関連ノート

読み込み中…