N-(2-Hydroxyethyl)imidazole → 7-[2-(1H-Imidazolyl)ethoxy]-2,2-dimethyl-4-chromanone

反応式

[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:14])[CH2:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.O[CH2:16][CH2:17][N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1>>[N:18]1([CH2:17][CH2:16][O:1][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:14])[CH2:7][C:8]([CH3:12])([CH3:13])[O:9]3)=[CH:4][CH:3]=2)[CH:22]=[CH:21][N:20]=[CH:19]1

参加物

反応物 2

HCID 74168N-(2-Hydroxyethyl)imidazole

HCID 6009027-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one

生成物 1

HCID 186265237-[2-(1H-Imidazolyl)ethoxy]-2,2-dimethyl-4-chromanone

実験手順

Following the procedure of Example 30 but using 7-hydroxy-2,2-dimethyl-4-chromanone and 1-(2-hydroxyethyl)imidazole, there was obtained the title compound as a solid, mp 84-86° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 287 (M+H+).

出典と根拠

ORDレコード: ord-a92fc503c73043c686e1c39952bfb854
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133303

反応ノート

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