Ethyl N-(oxomethylidene)valinate → HCID 23288448、化合物
反応式
[N:1]([CH:4]([CH:10]([CH3:12])[CH3:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[C:2]=[O:3].[OH:13][C:14]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:15]=1[NH2:16]>CN(C=O)C>[OH:13][C:14]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:15]=1[NH:16][C:2]([NH:1][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH:10]([CH3:11])[CH3:12])=[O:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of ethyl 2-isocyanato-3-methybutyrate (333 mg, 1.95 mmol) in DMF (1.0 ml), 2-hydroxy-4-nitroaniline (300 mg, 1.95 mmol) was added. The reaction mixture was stirred at 80° C. for 16 hours. Chromatography of the resulting liquid on silica gel gave desired product (420 mg, 66%). EI-MS m/z 326 (M+).