Chlorodimethylphenylsilane → n,n-Diethyl-2-chloro-6-(dimethylphenylsilyl)benzamide
反応式
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH3:15][Si:16](Cl)([CH3:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[C:10]([Si:16]([CH3:23])([CH3:15])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:14]参加物
3
実験手順
The title compound was prepared from the compound of Example e and 1.1 eq dimethylphenylsilyl chloride according to General Method A. Purification by HPLC with 1:9 ethyl acetate/hexanes gave 6.3 g of the desired product as a clear oil, a 91% yield.
後処理
- customPurification by HPLC with 1:9 ethyl acetate/hexanes
出典と根拠
- ORDレコード
- ord-2369a7a7151e4673a5f780d38ab28100
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133252
反応ノート
読み込み中…