Urea → 5-Chloro-1,3-dihydro-6-nitro-2H-benzimidazol-2-one

HRID 36867ノート

反応式

HRID 36867 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:12])[C:5]([NH2:11])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].N[C:14](N)=[O:15]>>[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]2[NH:11][C:14](=[O:15])[NH:12][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 1176UreaHCID 57026184-Chloro-5-nitro-o-phenylenediamine

生成物 1

HCID 145662265-Chloro-1,3-dihydro-6-nitro-2H-benzimidazol-2-one

実験手順

A mixture of 14 g (0.074 mol) of 4-chloro-5-nitro-1,2-benzenediamine and of 13.44 g (0.226 mol) of urea is heated at 180° C. for 4 hours. The reaction mixture is cooled and evaporated to dryness. The residue is taken up in methanol and evaporated again. The residue is triturated in ether and a solid is obtained which is filtered. The product is used as is in the subsequent stages.

後処理

  1. temperatureThe reaction mixture is cooled
  2. customevaporated to dryness
  3. customevaporated again
  4. customThe residue is triturated in ether
  5. customa solid is obtained which
  6. filtrationis filtered

出典と根拠

ORDレコード
ord-48938a94b76547d78882f6917891a754
出典データセット
uspto-grants-1995_05
特許番号
US05418241

反応ノート

読み込み中…