関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbon Dioxide | HCID 280 | — |
| 反応物 | 3,4-Dibromothiophene | HCID 18452 | — |
| 反応物 | HCID 178418306 | HCID 178418306 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Pentane | HCID 8003 | — |
| 生成物 | 4-Bromo-3-thenoic acid | HCID 85546 | 70.3% |
反応手順
To a solution of 3,4-dibromothiophene (15 g, 62 mmol) in 80 mL ether under a positive nitrogen atmosphere was added dropwise 75 mL 1.7M t-BuLi in pentane at below -73° C. and the resulting reaction solution was stirred at -78° C. for 0.5 h. After that, the ether solution was poured into dry ice and extracted with water. The aq solution was washed with ether and then acidified with concentrated HCl. The solid was filtered and air-dried to give 9 g of 4-bromo-3-thiophenecarboxylic acid, yield 70.3%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06133252 |
|---|
| 出典データセット | uspto-grants-2000_10 |
|---|
| ORD ID | ord-6212e6e68c5b487ea0df8610456e50d7 |
|---|
| 出典メモ | uspto-grants-2000_10 |
|---|
