Potassium Hydroxide → 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran

HRID 36874ノート

反応式

HRID 36874 の反応式
Br[CH:2]1[CH:7]([OH:8])[C:6]2[CH:9]=[C:10]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][C:5]=2[O:4][C:3]1([CH3:21])[CH3:20].[OH-].[K+]>C(OCC)C>[CH3:20][C:3]1([CH3:21])[CH:2]2[O:8][CH:7]2[C:6]2[CH:9]=[C:10]([C:13]([F:19])([F:18])[C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:12][C:5]=2[O:4]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 193706513-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol

生成物 1

HCID 199363903,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran収率 96.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 1.5 l of diethyl ether was added 12.63 g (33.67 mmol) of 3-bromo-3,4-dihydro-2,2-dimethyl-6-pentafluoroethyl-2H-1-benzopyran-4-ol synthesized according to the process of JP-B-2-237985, and 30.2 g of potassium hydroxide was added thereto, followed by stirring at room temperature for 54 hours. The insoluble material was removed by filtration, and the solvent was removed by distillation under reduced pressure to yield 9.5 g (96.2%) of 3,4-dihydro-2,2-dimethyl-3,4-epoxy-6-pentafluoroethyl-2H-1-benzopyran.

後処理

  1. customsynthesized
  2. additionwas added
  3. customThe insoluble material was removed by filtration
  4. customthe solvent was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-fe95702c48d94bb29eb304e32c6b377b
出典データセット
uspto-grants-1995_05
特許番号
US05418232

反応ノート

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