1-(3-Chlorophenyl)piperazine dihydrochloride → 1-(3-Chlorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride

HRID 368815

反応式

HRID 368815 の反応式
[ClH:1].Cl.[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1.O.Cl.Cl.[CH:19]1([CH2:29][CH2:30]N2CCN(C3C=CC=CC=3OC)CC2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][O:20]1>>[ClH:3].[ClH:1].[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][N:13]([CH2:30][CH2:29][CH:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][CH2:21][O:20]3)[CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

参加物

3

反応物 2

HCID 119574871-(3-Chlorophenyl)piperazine dihydrochlorideHCID 232889511-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate2 回

生成物 1

HCID 232887801-(3-Chlorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride

実験手順

Following the general procedure of EXAMPLE 1 and making non-critical variations but using 1-(3-chlorophenyl)piperazine dihydrochloride (XI, 0.5169 g (1.92 mmol) in place of 1-(2-chlorophenyl)piperazine dihydrochloride (XI), the title compound is obtained, mp 176.75-179°; MS (m/z) 356; IR (mineral oil) 2269, 2295, 2166, 2130, 2200 and 1449 cm-1.

出典と根拠

ORDレコード
ord-7675d92144fb4f9ebc278ad9d22096b5
出典データセット
uspto-grants-2000_10
特許番号
US06133446

関連ノート

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