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Ethyl formate → 1-Formyl-4-(4-methoxyphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl formate | HCID 8025 | — |
| 反応物 | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| 生成物 | 1-Formyl-4-(4-methoxyphenyl)piperazine | HCID 23288771 | — |
反応手順
A mixture of 1-(4-methoxyphenyl)piperazine (XI, 7.41 g) and ethyl formate (108 ml) is stirred at reflux for 3 hr. The mixture is then cooled, concentrated, and the residue chromatographed on silica gel eluting with methanol/dichloromethane (2/98). The appropriate fractions are pooled and concentrated to give 1-formyl-4-(4-methoxyphenyl)piperazine (VI), NMR (CDCl3) δ 3.05, 3.54, 3.71, 3.78, 6.88, 8.10.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133446 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-bf36939d21b241d38a0977748842d6d1 |
| 出典メモ | uspto-grants-2000_10 |