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(6-Bromoisochroman-1-yl)acetic acid → 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (6-Bromoisochroman-1-yl)acetic acid | HCID 10540012 | — |
| 反応物 | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| 反応物 | 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine | HCID 54184920 | — |
| 生成物 | 1-(3,4-Dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)ethyl]piperazine | HCID 15487835 | — |
反応手順
(6-Bromoisochroman-1-yl)acetic acid (EXAMPLE 22, LXVIII) is coupled with 3,4-dichlorophenylpiperazine (XI) and the resulting amide, 1-(3,4-dichlorophenyl)-4-[2-(6-bromoisochroman-1-yl)]acetyl piperazine (LXIII, 1.66 mmol) is reduced following the general procedure of EXAMPLE 50 and making non-critical variations, to give the title compound, HRMS Calcd for C21H23N2O1Br1Cl2 =468.0371, found=418.0363.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133446 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-0f98be8bb4ac480198b31f22d9a190ac |
| 出典メモ | uspto-grants-2000_10 |