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HRID 368868作成日：2026年10月27日

4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-3-Bromo-4-[4-[2-(6-bromoisochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide

https://huagongshe.com/reaction/368868

反応式

関与物質

役割名称HCID仕込み量
反応物4-(Piperazin-1-yl)benzene-1-sulfonamideHCID 901897—
反応物2-(6-Bromoisochroman-1-yl)ethanolHCID 23288830—
反応物3-Bromo-4-(piperazin-1-yl)-benzenesulfonamide hydrochlorideHCID 23288838—
反応物1-(2-Bromo-4-methoxyphenyl)piperazineHCID 23288928—
生成物(S)-(-)-3-Bromo-4-[4-[2-(6-bromoisochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamideHCID 54523419—

反応手順

Following the general procedure of EXAMPLE 49 and making non-critical variations, 2-(6-bromoisochroman-1-yl)ethanol (LXXIX, 0.399 g) and 3-bromo-4-(piperazin-1-yl)- benzenesulfonamide hydrochloride (VIII, Chart C, 0.544 g; prepared by the method of EXAMPLE 37 but using 4-(piperazin-1-yl)benzenesulfonamide (IV) in place of 1-(4-methoxyphenyl)piperazine) are combined to give the title compound; mp 206-208°; MS (m/z) 557 and 559; IR (mineral oil) 1165, 1338, 1450, 616, 1586 and 731 cm-1.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06133446
出典データセットuspto-grants-2000_10
ORD IDord-73d7d63e4ffc4b4b81b5d8590bff1598
出典メモuspto-grants-2000_10