化工社化工社 化学情報印刷レポート · 研究参考用
4-(Piperazin-1-yl)benzene-1-sulfonamide → 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| 反応物 | (-)-2-(Isochroman-1-yl)ethanol | HCID 14141298 | — |
| 生成物 | 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide | HCID 10811059 | — |
反応手順
Following the general procedure of EXAMPLE 49 and making non-critical variations 2-(isochroman-1-yl)ethanol (LXXIX, (+)-enantiomer, 0.6045 g) and 4-(piperazin-1-yl)benzenesulfonamide (IV, 0.9824 g) are combined to give the title compound, mp 189-190°; MS (m/z) 401; [α]D +48 (c 0.877, DMF); IR (mineral oil) 1662, 1594, 1150, 1101, 614 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133446 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-67c5e8aca1214ce6ae6cd55953054aed |
| 出典メモ | uspto-grants-2000_10 |