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HRID 368876作成日：2026年10月27日

4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamide

https://huagongshe.com/reaction/368876

反応式

関与物質

役割名称HCID仕込み量
反応物4-(Piperazin-1-yl)benzene-1-sulfonamideHCID 901897—
反応物(-)-2-(Isochroman-1-yl)ethanolHCID 14141298—
反応物4-(Homopiperazin-1-yl)benzenesulfonamideHCID 17792895—
反応物1-(2-Chloroethyl)-4-methyl-isochromanHCID 23288938—
反応物(4S)-4-(phenylmethyl)-3-(2-phenylpropionyl)-2-oxazolidinoneHCID 56980759—
生成物(S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamideHCID 53677310—

反応手順

Following the general procedure for EXAMPLE 48 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX) and 4-(homopiperazin-1-yl)benzenesulfonamide (IV; prepared from 4-fluorobenzenesulfonamide (III) and homopiperazine (II, Aldrich) by the method of EXAMPLE 47 Step 1) give the title compound, MS (m/z) 415; [α]D -50° (c 0.9996, methylene chloride); IR (mineral oil) 1153, 1595, 1102, 1511 and 1316 cm-1.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06133446
出典データセットuspto-grants-2000_10
ORD IDord-d0641541927a4557861986c670484f48
出典メモuspto-grants-2000_10