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Acetonitrile → 2-(2-Naphthyl)N-allyidimethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N,N-Dimethylallylamine | HCID 75082 | — |
| 反応物 | 2-Naphthyl Trifluoromethanesulfonate | HCID 4546341 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 触媒 | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(2-Naphthyl)N-allyidimethylamine | HCID 54313775 | 64% |
反応手順
Table 1, Entry 9. In the reaction tube were mixed 2-naphthyl triflate (0.276 g, 1.0 mmol), N-allyidimethylamine (0.426 g, 5.0 mmol), palladium acetate (0.00673 g, 0.030 mmol), DPPF (0.0366 g, 0.066 mmol), potassium carbonate (0.207 g, 1.5 mmol) and 1.0 ml acetonitrile.under nitrogen. The contents of the flask were irradiated for 5.00 min with an effect of 50 W. After cooling, the product mixture was poured into 25 ml water and was extracted three times with 25 ml diethyl ether. The combined extracts were washed two times with 25 ml saline and concentrated to an oil. The crude product was purified by repeated Kugelrohr distillation. The yield was 64% (clear oil).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136157 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-9234f45069e04d55a75e3e075be1fe64 |
| 出典メモ | uspto-grants-2000_10 |