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Triethylamine → Vinyl 4-[(5-bromo-1H-indol-3-yl)thio]piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Vinyl chloroformate | HCID 78808 | — |
| 反応物 | 5-bromo-3-(piperidin-4-ylthio)-1H-indole | HCID 19936667 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Vinyl 4-[(5-bromo-1H-indol-3-yl)thio]piperidine-1-carboxylate | HCID 19936620 | — |
反応手順
Vinyl chloroformate (0.75 ml) is added dropwise to a solution of triethylamine (1.2 ml) and 5-bromo-3-(piperidin-4-ylthio)-1H-indole (2.5 g, prepared in Example 49) in dichloromethane (25 ml) at 0° C. After 2 hours at room temperature, the solution is washed with water. The organic phase is dried over magnesium sulfate and concentrated. Vinyl 4-[(5-bromo-1H-indol-3-yl)thio]piperidine-1-carboxylate (1.8 g) is obtained after chromatography on silica gel (eluent: cyclohexane/AcOEt 70/30).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418242 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-1b910d7bef7849f3b7e40343de7732e6 |
| 出典メモ | uspto-grants-1995_05 |