Homoveratrylamine → N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

HRID 368998

反応式

HRID 368998 の反応式
[C:1]([O:11]C)(=O)[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH2:25])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH2:23][CH2:24][NH:25][C:1](=[O:11])[CH:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[OH:3])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

参加物

3

反応物 2

HCID 8421HomoveratrylamineHCID 78066(+-)-Methyl mandelate

生成物 1

HCID 596397N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-hydroxy-2-phenylacetamide

実験手順

33.2 g (0.2 Mol) of methyl mandelate and 72 g (0.4 Mol) of 2-(3,4-dimethoxyphenyl)-ethylamine are heated to 160-165° C. under an N2 atmosphere with stirring, for 5 hours using a descending condenser (to remove the methanol released). The cooled residue is dissolved in 300 ml of ethyl acetate, washed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution, dried over MgSO4 and distilled off from the solvent.

後処理

  1. customto remove the methanol
  2. dissolutionThe cooled residue is dissolved in 300 ml of ethyl acetate
  3. washwashed twice with 100 ml of 2N HCl, once with saturated NaHCO3 solution and saturated NaCl solution
  4. dry with materialdried over MgSO4
  5. distillationdistilled off from the solvent

出典と根拠

ORDレコード
ord-dcac017363dc466e9fefe95c7fe9a456
出典データセット
uspto-grants-2000_10
特許番号
US06136819

関連ノート

読み込み中…