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Isopropanol → Isopropyl Hydrogen Phenylmalonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Phenylmalonic acid | HCID 75791 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Isopropyl Hydrogen Phenylmalonate | HCID 19042994 | 60% |
反応手順
Phenylmalonic acid (13.5 g, 0.07 mol ) in dry ether (40 mL) was treated with thionyl chloride (8.92 g, 5.4 mL, 0.07 mol) and one drop of N,N-dimethylformamide. The mixture was heated at 40°-50° C. for 3 hours. The clear solution was evaporated under reduced pressure to remove any residual thionyl chloride. The oily residue was redissolved in dry ether (40 mL), and the solution was treated with isopropyl alcohol (0.075 mol, 5.76 mL), refluxed for 2 hours and worked up as before to give the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418244 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-af73ff0456864c18a081b75ef0069f5f |
| 出典メモ | uspto-grants-1995_05 |