Potassium Hydroxide → 6-Ethynyl-8-(3-nitrophenyl)-1,7-naphthyridine

HRID 369032ノート

反応式

HRID 369032 の反応式
C[Si]([C:5]#[C:6][C:7]1[CH:8]=[C:9]2[C:14](=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=3)[N:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)(C)C.[OH-].[K+]>CO.C1(C)C=CC=CC=1>[C:6]([C:7]1[CH:8]=[C:9]2[C:14](=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-:25])=[O:24])[CH:18]=3)[N:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)#[CH:5]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 232846376-Trimethylsilylethynyl-8-(3-nitrophenyl)-1,7-naphthyridine

生成物 1

HCID 232846336-Ethynyl-8-(3-nitrophenyl)-1,7-naphthyridine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 1140Toluene溶媒

実験手順

To a solution of 6-trimethylsilylethynyl-8-(3-nitrophenyl)-1,7-naphthyridine (77 mg, 0.22 mmol) in methanol (0.5 ml) and toluene (0.5 ml) is added 1N potassium hydroxide (0.22 ml). The mixture was stirred for 2 h. The suspension is filtered and the product washed with water and ether affording the title compound. Mass M+H 276; mp 215° C. decomposition.

後処理

  1. filtrationThe suspension is filtered
  2. washthe product washed with water and ether affording the title compound

出典と根拠

ORDレコード
ord-c5ee397d2fb543bab80f86cccb41b574
出典データセット
uspto-grants-2000_10
特許番号
US06136821

反応ノート

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