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4-Hydrazinylbenzenesulfonamide hydrochloride → 4-[5-(6-chlorobenzothiazol-2-yl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydrazinylbenzenesulfonamide hydrochloride | HCID 2794567 | — |
| 反応物 | 4,4,4-Trifluoro-1-(6-chlorobenzothiazol-2-yl)butane-1,3-dione | HCID 23285375 | — |
| 生成物 | 4-[5-(6-chlorobenzothiazol-2-yl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide | HCID 23285420 | — |
反応手順
The procedure of Example 9 was repeated using 4,4,4-trifluoro-1-(6-chlorobenzothiazol-2-yl)butane-1,3-dione and 4-sulfamoylphenylhydrazine hydrochloride as the starting materials to obtain 4-[5-(6-chlorobenzothiazol-2-yl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonamide. NMR(CDCl3 -DMSO-d6) δ: 6.91 (2H, bs), 7.30-7.49 (2H, m), 7.63 (2H, d, J=8.9 Hz), 7.88-7.91 (2H, m), 8.05 (2H, d, J=8.9 Hz); mp 254-255° C. (ethanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136831 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-c274906ee8e74ad28bcd35a3ed1c5375 |
| 出典メモ | uspto-grants-2000_10 |