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Hydrochloric Acid → (S)N-(2-mercapto-1-oxo-3-phenylpropyl) D-Tryptophan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | L-Tryptophan | HCID 6305 | — |
| 反応物 | D-Tryptophan | HCID 9060 | — |
| 反応物 | (S)-2-(benzoylthio)-3-phenylpropanoic acid | HCID 9878985 | — |
| 反応物 | (R)-2-(benzoylthio)-3-phenylpropanoic acid | HCID 9943761 | — |
| 生成物 | (S)N-(2-mercapto-1-oxo-3-phenylpropyl) D-Tryptophan | HCID 57125133 | — |
反応手順
The operation is carried out as in Stage 1 of Example 24 using, instead of the hydrochloride of the methyl ester of L-Tryptophan, the hydrochloride of the methyl ester of D-Tryptophan and, instead of (R)-2-(benzoylthio)-3-phenylpropanoic acid, (S)-2-(benzoylthio)-3-phenylpropanoic acid (prepared according the same reference). After purification by chromatography on silica with a methylene chloride-ethyl acetate: 95-5 mixture as eluant, 564 mg of expected product (SR isomer) (colourless foam) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136842 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-0fa0366102284a0d975afc5404871b5f |
| 出典メモ | uspto-grants-2000_10 |