Ethyl Acetate → Indane

HRID 36926

反応式

HRID 36926 の反応式
ClC1C=CC=CC=1C(Cl)=O.N[C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][CH2:16][CH2:15]2.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>O>[CH2:17]1[C:18]2[C:14](=[CH:13][CH:12]=[CH:20][CH:19]=2)[CH2:15][CH2:16]1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 691102-Chlorobenzoyl chlorideHCID 90496Indan-5-amine

生成物 1

HCID 10326Indane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Chlorobenzoyl chloride (11.8 g) was added dropwise to a stirred mixture of 5-aminoindan (9.0 g), potassium carbonate (9.3 g), ethyl acetate (90 ml) and water (90 ml) under ice-cooling. The mixture was further stirred under ice-cooling for one hour, at the end of which time the organic layer was separated, washed with water, dried (MgSO4) and distilled to remove the solvent. The procedure gave crystals of 5-2-chlorobenzoylamino)indan. The crystals were collected by filtration and recrystallized from isopropyl ether to give colorless needles, m.p. 144°-145° C.

後処理

  1. temperaturecooling
  2. temperaturecooling for one hour, at the end of which time the organic layer
  3. customwas separated
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. distillationdistilled
  7. customto remove the solvent

出典と根拠

ORDレコード
ord-88d69e93a5f6475badf02e8876958cbe
出典データセット
uspto-grants-1995_05
特許番号
US05418239

関連ノート

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