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Acetyl chloride → 3-[4-(4-p-Methoxyphenylpiperazino)butyl]-5-acetamidoindole, hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 5-Nitroindole | HCID 22523 | — |
| 反応物 | 3-[4-(4-p-Methoxyphenylpiperazino)butyl]-5-aminoindole | HCID 19936462 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-[4-(4-p-Methoxyphenylpiperazino)butyl]-5-acetamidoindole, hydrochloride | HCID 131719008 | — |
反応手順
A solution of 3.5 g of 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-aminoindole ["D"; obtainable by reduction of the corresponding 5-nitroindole] in 35 ml of THF is treated with a solution of 0.9 g of acetyl chloride in 10 ml of THF, and the mixture is stirred for 2 hours at 50°, evaporated and worked up in a conventional manner. 3-[4-(4-p-Methoxyphenylpiperazino)butyl]-5-acetamidoindole, hydrochloride, m.p. 240° (dec.) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418237 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-f03189a9faa146608c9b39960fa1611d |
| 出典メモ | uspto-grants-1995_05 |