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Diethylene Glycol Monoethyl Ether → 3-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-[4-(4-m-Methoxyphenylpiperazino)butyl]-5-cyanoindole | HCID 19936482 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[4-(4-m-Methoxyphenylpiperazino)butyl]indole-5-carboxamide | HCID 19936456 | — |
反応手順
A mixture of 30.6 g of 3-[4-(4-m-methoxyphenylpiperazino)butyl]-5-cyanoindole, 27.1 g of NaOH, 520 ml of water and 420 ml of diethylene glycol monoethyl ether is stirred for 3 hours at a bath temperature of 140°. It is cooled and worked up in a conventional manner, and 3-[4-(4-m-methoxyphenylpiperazino)butyl]indole-5-carboxamide is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418237 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-f6566778685e4c7d97edb5d95ee8c66c |
| 出典メモ | uspto-grants-1995_05 |