Hydrochloric Acid → Ethyl 3-hydroxy-3-(4-acetoxyphenyl)propionate

HRID 369693

反応式

HRID 369693 の反応式
[C:1]([O:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:10])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].N.B.Cl>CCOCC>[OH:10][CH:9]([C:8]1[CH:7]=[CH:6][C:5]([O:4][C:1](=[O:3])[CH3:2])=[CH:18][CH:17]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 419330Ammonia;boraneHCID 23282454Ethyl 3-(4-acetoxyphenyl)-3-oxopropanoate

生成物 1

HCID 15890183Ethyl 3-hydroxy-3-(4-acetoxyphenyl)propionate収率 57.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A 250 ml round bottom flask was charged with 11.25 grams (0.045 mol.) of ethyl 4-acetoxy-benzoylacetate and 150 ml of diethyl ether. The solution was stirred and ammonia-borane (1.39 gm., 0.045 mol., Alfa) was added in 4 portions. After being stirred 90 minutes at room temperature 50 ml of ether were added and the reaction mixture was slowly poured into a 400 ml beaker containing 20 ml of 3 N HCl and 100 ml of crushed ice. After 15 minutes the organic phase was separated. The aqueous phase was extracted with ether (2×100 ml). The combined organic phase was washed with brine, dried over magnesium sulfate, filtered and evaporated. The crude product was purified by flash chromatography, using a 7 cm. diameter column of 250 grams silica gel, packed and eluted with 25% ethyl acetate/petroleum ether. 6.53 grams of ethyl 3-hydroxy-3-(4-acetoxyphenyl)propionate was obtained. The product was identical to that obtained by method A as determined by NMR and elemental analysis.

後処理

  1. additionwere added
  2. additionthe reaction mixture was slowly poured into a 400 ml beaker
  3. customAfter 15 minutes the organic phase was separated
  4. extractionThe aqueous phase was extracted with ether (2×100 ml)
  5. washThe combined organic phase was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated
  9. customThe crude product was purified by flash chromatography
  10. washeluted with 25% ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-c5df3861d2ae4ffcb7347e5169413208
出典データセット
uspto-grants-2000_10
特許番号
US06140310

関連ノート

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