4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4amino-phenyl)-7H-pyrrolo[2.3-d]-pyrimidine

HRID 369715

反応式

[N:1]1([C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1>[Ni].C1(C)C=CC=CC=1.CC(C)=O>[N:1]1([C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:21]=[CH:22][C:23]([NH2:26])=[CH:24][CH:25]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

実験手順

This product is obtained in a manner analogous to that described in Example 7 by hydrogenation of 4-(1,2,3,4-tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine (Example 10) with Raney nickel. M.p. 243-245° C.; FAB-MS: (M+H)+ =342 (corresponds to C21H19N5); Rf value (toluene-acetone--4:6)=0.25.

後処理

customThis product is obtained in a manner analogous to

出典と根拠

ORDレコード: ord-b5fecb1b1a8d434d917ad74f33cfe993
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06140317

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

関連ノート