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Bromomethyl 2-methoxyphenyl ketone → 2-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromomethyl 2-methoxyphenyl ketone | HCID 123440 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Ethyl 2-carbamimidoylacetate hydrochloride | HCID 15555354 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Amino-3-ethoxycarbonyl-5-(2-methoxy-phenyl)-1H-pyrrole | HCID 23282699 | — |
反応手順
Analogously to Step 8.1, 14.5 g (87 mmol) of 2-amidino-acetic acid ethyl ester hydrochloride in 150 ml of abs. ethanol are reacted with 5.9 g (87 mmol) of sodium ethanolate and 10.3 g (44 mmol) of 2-bromo-1-(2-methoxy-phenyl)-ethan-1-one (2-bromo-2'-methoxy-acetophenone; Aldrich; Milwaukee/USA) to form the title compound; m.p.: 128° C.; TLC-Rf =0.25 (hexane/ethyl acetate [2:1]).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06140332 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-2a49f028cf6f4743b9ad849985078b6a |
| 出典メモ | uspto-grants-2000_10 |