2-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine → Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone

HRID 369883ノート

反応式

HRID 369883 の反応式
[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2CC2C=CC=CC=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

4

反応物 1

HCID 232826462-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine

生成物 1

HCID 550904Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone収率 92.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

In ethanol (300 ml) is suspended 5% palladium-carbon (3 g), and thereto is added 2-(1-pyrrolidinyl)carbonyl-1-benzylpyrrolidine (30 g), and the mixture is subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The mixture is filtered, and the filtrate is concentrated under reduced pressure to remove the solvent to give 2-(1-pyrrolidinyl)carbonylpyrrolidine (about 18 g) as an oily product.

後処理

  1. customis subjected to catalytic hydrogenation at room temperature under atmospheric pressure
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customto remove the solvent

出典と根拠

ORDレコード
ord-3fc5a98fccb24020a84daa4a512926d3
出典データセット
uspto-grants-2000_10
特許番号
US06140330

反応ノート

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