3-Methoxy-4-methoxycarbonylcinnamic acid → 3-(3-Methoxy-4-methoxycarbonylphenyl)propionic acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])[CH:6]=[CH:7][C:8]([OH:10])=[O:9]>C(O)(=O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15]参加物
4
実験手順
To a suspension of 3-methoxy-4-methoxycarbonylcinnamic acid (8.35 g) in acetic acid (200 ml) is added 10% palladium-carbon (1.0 g), and the mixture is subjected to hydrogenation at room temperature. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is crystallized from diethyl ether-n-hexane to give 3-(3-methoxy-4-methoxycarbonylphenyl)propionic acid (7.5 g).
後処理
- customis subjected to hydrogenation at room temperature
- customThe catalyst is removed by filtration
- concentrationthe filtrate is concentrated under reduced pressure
- customThe residue is crystallized from diethyl ether-n-hexane
出典と根拠
- ORDレコード
- ord-c7f664acf0934378873049caccf90656
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06140330
反応ノート
読み込み中…