1-[2-(1-Adamantyl)ethyl]-2-n-butyl-5-hydroxymethyl-imidazole → 1-[2-(1-Adamantyl)ethyl]-2-n-butyl-imidazol-5-carboxaldehyde

HRID 36990ノート

反応式

HRID 36990 の反応式
[C:1]12([CH2:11][CH2:12][N:13]3[C:17]([CH2:18][OH:19])=[CH:16][N:15]=[C:14]3[CH2:20][CH2:21][CH2:22][CH3:23])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[C:1]12([CH2:11][CH2:12][N:13]3[C:17]([CH:18]=[O:19])=[CH:16][N:15]=[C:14]3[CH2:20][CH2:21][CH2:22][CH3:23])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 1

HCID 199368601-[2-(1-Adamantyl)ethyl]-2-n-butyl-5-hydroxymethyl-imidazole

生成物 1

HCID 199369031-[2-(1-Adamantyl)ethyl]-2-n-butyl-imidazol-5-carboxaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 1140Toluene溶媒

実験手順

The above prepared compound (5.4 g) was stirred at room temperature with potassium hydroxide (5.2 g) in ethanol (200 ml) for one hour. The mixture was concentrated, poured into water, stirred and filtered to give 1-[2-(1-adamantyl)ethyl]-2-n-butyl-5-hydroxymethyl-imidazole. The hydroxymethyl group was oxidized by refluxing the imidazole compound (51.1 g) with manganese dioxide (20.3 g) in toluene (200 ml) to give 1-[2-(1-adamantyl)ethyl]-2-n-butyl-imidazol-5-carboxaldehyde.

出典と根拠

ORDレコード
ord-5ca69039501649b5a557b667f98d3fb6
出典データセット
uspto-grants-1995_05
特許番号
US05418250

反応ノート

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