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HRID 36991作成日：2026年10月26日

4-Methoxybenzyl alcohol → p-Methoxybenzyl acrylate

https://huagongshe.com/reaction/36991

反応式

関与物質

役割名称HCID仕込み量
反応物4-Methoxybenzyl alcoholHCID 7738—
反応物(E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acidHCID 70041240—
生成物p-Methoxybenzyl acrylateHCID 346146—

反応手順

(E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid, prepared as in Example 19, is esterified with 4-methoxy-benzyl alcohol to give the p-methoxybenzyl propenoate. The 4-hydroxymethyl group in acetone is oxidized using an acidic aqueous solution containing chromic acid (Jones' reagent) and the ester is hydrolyzed using 10% sodium hydroxide to give the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05418250
出典データセットuspto-grants-1995_05
ORD IDord-3862763d9dd040f2bdcc091619a783c9
出典メモuspto-grants-1995_05