化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-(hydroxymethyl)benzoate → (E)-3-[2-n-Propyl-1-{(4-carboxyphenyl)methyl}-1h-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(hydroxymethyl)benzoate | HCID 81325 | — |
| 反応物 | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | HCID 10047444 | — |
| 反応物 | Methyl ether hydrochloride | HCID 21585225 | — |
| 生成物 | (E)-3-[2-n-Propyl-1-{(4-carboxyphenyl)methyl}-1h-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid | HCID 36688250 | — |
反応手順
The title compound was prepared using the procedure of Example 1 replacing valermamidine methyl ether hydrochloride with butyramidine methyl ether hydrochloride and replacing 2-chlorbenzyl alcohol with 4-carbomethoxybenzyl alcohol; mp 250° C. (d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418250 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-e5ef573c113d47ec8a15fb229397ea93 |
| 出典メモ | uspto-grants-1995_05 |