Methanol → Methyl 3-methyl-4-nitrobenzoate

HRID 370016

反応式

HRID 370016 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14]O>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([O:7][CH3:14])=[O:6]

参加物

3

反応物 2

HCID 887MethanolHCID 183703-Methyl-4-nitrobenzoic acid

生成物 1

HCID 260927Methyl 3-methyl-4-nitrobenzoate

実験手順

In a 5-liter three-necked round-bottomed flask equipped with a reflux condenser, overhead stirrer and gas inlet, was placed 300 g of 3-methyl-4-nitrobenzoic acid and 3 l of methanol. To the resulting well-stirred solution was bubbled in 20.8 g of hydrogen chloride and the resulting mixture was refluxed for 3 hours. The reaction mixture was cooled to room temperature and allowed to stand overnight. The expected methyl 3-methyl-4-nitrobenzoate precipitated as light yellow crystals, which were collected by suction filtration yielding after drying 259.3 g. This solid was used as such in the next step.

後処理

  1. customIn a 5-liter three-necked round-bottomed flask equipped with a reflux condenser
  2. customwas bubbled in 20.8 g of hydrogen chloride
  3. temperaturethe resulting mixture was refluxed for 3 hours
  4. customThe expected methyl 3-methyl-4-nitrobenzoate precipitated as light yellow crystals, which
  5. filtrationwere collected by suction filtration
  6. customyielding
  7. customafter drying 259.3 g

出典と根拠

ORDレコード
ord-4b272888a1134d9ead9ea5e64d083016
出典データセット
uspto-grants-2000_10
特許番号
US06140362

関連ノート

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