化工社化工社 化学情報印刷レポート · 研究参考用
N-Iodosuccinimide → 2-n-Butyl-5-hydroxymethyl-4-iodoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Iodosuccinimide | HCID 120273 | — |
| 反応物 | HCID 178418407 | HCID 178418407 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-n-Butyl-5-hydroxymethyl-4-iodoimidazole | HCID 14898547 | 95.5% |
反応手順
N-Iodosuccinimide (148.75 g, 0.661 mol) was added to a stirred solution of 2-butyl-4-hydroxymethylimidazole (100.78 g, 0.652 mol) in 500 mL of absolute ethanol. After 20 minutes the solution was heated to 40°-45° C. for 45 minutes, diluted with 2.5 liters of water, and chilled. The crystalline product was collected by filtration, washed with water, and dried to give 174.5 g (95%) of crystals; mp 166°-166.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05418250 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-dba550157d9b489c8894daa59a6bd08b |
| 出典メモ | uspto-grants-1995_05 |