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Melatonin → HCID 15382325、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Melatonin | HCID 896 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 生成物 | HCID 15382325 | HCID 15382325 | — |
| 生成物 | N-[2-(1-acetyl-5-methoxyindol-3-yl)ethyl]diacetamide | HCID 44359266 | — |
反応手順
Melatonin (126 mg) is dissolved in tetrahydrofuran (10 ml) in a 50 ml round-bottomed flask, sodium hydride (200 mg) is then added and the mixture is maintained at reflux (10 min). After cooling (0° C.), acetyl chloride is added and the mixture is kept stirring overnight (room temperature). After filtration and dilution (EtOAc), the organic phase is washed with water and then separated on a silica plate. N-[2-(1-Acetyl-5-methoxyindol-3-yl)ethyl]acetamide (1) is mainly obtained, along with a side product, N-[2-(1-acetyl-5-methoxyindol-3-yl)ethyl]diacetamide (10) (cf. Example 10).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06140372 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-707afcc28a634645995c8dc135c38eae |
| 出典メモ | uspto-grants-2000_10 |