化工社化工社 化学情報印刷レポート · 研究参考用
5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Chloro-2-nitrobenzoic acid | HCID 17286 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-Chloro-2-nitrobenzoyl chloride | HCID 2723685 | 104.5% |
反応手順
To a suspension of 5-chloro-2-nitrobenzoic acid (21 g, 100 mmol) in dry methylene chloride (200 mL) at 0° C. were added several drops of DMF, followed by oxalyl chloride (13 mL, 150 mmol). The reaction was warmed to ambient temperature. After 16 hours the solvents were removed and the viscous oil dried in vacuo to afford 23 g (quantitative yield) of 5-chloro-2-nitrobenzoyl chloride; NMR (CDCl3) 8.1 (d, 1), 7.7 (m, 2) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06140351 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-334ab236062a4121888a04ebcb61115d |
| 出典メモ | uspto-grants-2000_10 |