2,3,5,6-Tetrafluorophenyl 5-(9-Acridinyl)pentanoate → 1-[5-(9-Acridinyl)-1-oxopentyl]-5-hydroxymethyl-(3R-trans)-3-pyrrolidinol
反応式
[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]([N:21]2[C@H:25]([CH2:26][OH:27])[CH2:24][C@@H:23]([OH:28])[CH2:22]2)=[O:20])=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1.C1C2C(=NC3C(C=2CCCCC(OC2C(F)=C(F)C=C(F)C=2F)=O)=CC=CC=3)C=CC=1>>[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1.[CH:1]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([C:13]=2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]([N:21]2[C@H:25]([CH2:26][OH:27])[CH2:24][C@@H:23]([OH:28])[CH2:22]2)=[O:20])=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
A procedure similar to that described in Example XXIV was used for the preparation of 21. 1.28 g (3.00 mmol) of acridine TFP ester 20 gave 1.04 g (92% yield) of 21 as a pale yellow solid foam: