Iodine → 2-Iodo-4-methylaniline

HRID 370357

反応式

HRID 370357 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[I:14]I>C(Cl)Cl.O>[I:14][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[NH2:1]

参加物

6

反応物 3

HCID 807IodineHCID 7813p-ToluidineHCID 516892Sodium Bicarbonate

生成物 1

HCID 27640002-Iodo-4-methylaniline

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of p-toluidine (5 g, 46.7 mmol) in methylene chloride (25 mL) was added a solution of sodium bicarbonate (4.7 g, 56 mmol) in water (75 mL). Then was added iodine (11.26 g, 44.33 mmol) in small portions and the mixture was stirred for 16 hours at room temperature. The reaction was quenched with saturated NaHSO3 and the product was extracted with methylene chloride. The methylene chloride layer was washed with brine, dried over Na2SO4, and evaporated in vacuo to give a crude 2-iodo-4-methylaniline.

後処理

  1. customThe reaction was quenched with saturated NaHSO3
  2. extractionthe product was extracted with methylene chloride
  3. washThe methylene chloride layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-03feabe7ed0f49ca985286056400081a
出典データセット
uspto-grants-2000_10
特許番号
US06140499

関連ノート

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