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m-Chlorophenylacetonitrile → Ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Chlorophenylacetonitrile | HCID 73722 | — |
| 反応物 | Pentanedioic acid, 3,3-dimethyl-, 1,5-diethyl ester | HCID 87314 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate | HCID 20275820 | 71% |
反応手順
Starting with 75.0 g (0.495 mol) of 3-chlorobenzyl cyanide, 160.58 g (0.743 mol) of diethyl 3,3-dimethylglutarate, 14.80 g (0.643 mol) of sodium, and 260 ml of dry ethanol a total of 108.08 g (71% yield) of the desired product was obtained using the procedure described in Example I, Part A.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04526723 |
| 出典データセット | uspto-grants-1985_07 |
| ORD ID | ord-4e9e4c131d5b4a46bf20b2e5f5c0468f |
| 出典メモ | uspto-grants-1985_07 |