Formic Acid → 6-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazine

HRID 370443

反応式

HRID 370443 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:9][NH2:10])=[CH:6][C:7]=1[CH3:8].[CH:11](O)=O>>[CH3:8][C:7]1[C:2]([Cl:1])=[N:3][N:4]2[CH:11]=[N:10][N:9]=[C:5]2[CH:6]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 123768133-Chloro-6-hydrazinyl-4-methylpyridazine

生成物 1

HCID 8197966-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazine

実験手順

13.4 Grams (0.0845 mole) of 3-chloro-4-methyl-6-hydrazinopyridazine are dissolved in 100 milliliters of aqueous 88 percent formic acid. The mixture is heated at the boiling temperature under reflux for 2 hours. The mixture is evaporated under reduced pressure and the 7-methyl-6-chloro-s-triazolo[4,3-b]pyridazine intermediate product is obtained as a residue. The residue is triturated with diethyl ether, and found to melt at a temperature of 157.5°-158° C.

後処理

  1. temperatureThe mixture is heated at the boiling temperature
  2. temperatureunder reflux for 2 hours
  3. customThe mixture is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2e044734cf3b4fb2b40bb6374d07745a
出典データセット
uspto-grants-1985_07
特許番号
US04526890

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